Author

E. M. Cornett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. A. Chomiak· 1 shared A. Hudmon· 1 shared C. A. Berryhill· 1 shared F. K. Sahoo· 1 shared J. N. Hanquier· 1 shared J. Z. Vilseck· 1 shared K. Sanders· 1 shared K. Thurlow· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. A. Chomiak

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2 papers

Recent·Most cited

Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling

A. A. Chomiak, R. Tiedemann, Y. Liu, X. Kong, Y. Cui, K. Thurlow, E. M. Cornett, M. J. Topper, S. Baylin, S. B. Rothbart

The paper shows that combining DNMT inhibitors with selective EZH2 inhibitors enhances antiproliferative effects in colon cancer by modulating calcium-calcineurin-NFAT signaling and viral mimicry.

bioRxiv · Jun 9, 2023Cancer Biology

Substrate selectivity of the PRDM9 lysine methyltransferase domain.

J. N. Hanquier, K. Sanders, C. A. Berryhill, F. K. Sahoo, A. Hudmon, J. Z. Vilseck, E. M. Cornett

This study identifies PRDM9's substrate selectivity, showing it preferentially methylates non-histone proteins over histones, with structural and biochemical validation.

bioRxiv · Oct 12, 2022Biochemistry