K. Sanders

Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans

This study shows that sinefungin, a nucleoside analog, reduces the pathogenicity of C. albicans by impairing hyphal growth, biofilm formation, and adhesion to human cells without harming human cells.

Substrate selectivity of the PRDM9 lysine methyltransferase domain.

This study identifies PRDM9's substrate selectivity, showing it preferentially methylates non-histone proteins over histones, with structural and biochemical validation.

Structure of the two-component S-layer of the archaeon Sulfolobus acidocaldarius

The paper determines the atomic structure of the two-component S-layer in Sulfolobus acidocaldarius using cryoEM, cryoET, and AlphaFold2.

A comparison of six DNA extraction protocols for 16S, ITS, and shotgun metagenomic sequencing of microbial communities

The paper compares six DNA extraction protocols for 16S, ITS, and shotgun metagenomic sequencing, finding the MagMAX Microbiome kit performs best across multiple criteria.

Circulating microRNAs as noninvasive biomarkers for canine Cushing's syndrome

This study identifies circulating microRNAs as potential noninvasive biomarkers for canine Cushing's syndrome, showing differential expression in pituitary-dependent and adrenal tumors and recurrence prediction.

CryoEM structure of the outer membrane secretin channel pIV from the f1 filamentous bacteriophage

The paper determines the cryo-EM structure of the phage secretin pIV from f1 bacteriophage, models its function, and compares it to bacterial secretins.

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

A comparison of DNA/RNA extraction protocols for high-throughput sequencing of microbial communities

The paper compares DNA/RNA extraction protocols for microbial community sequencing, finding one protocol equivalent or better than a standard DNA-only method for RNA-based organisms.

Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the colon

This study investigates Ca2+ signaling in submucosal interstitial cells of Cajal (ICC-SM) and its role in driving smooth muscle contractions in the colon.

A new twist on bacterial motility - Two distinct type IV pili revealed by cryoEM

This study identifies two distinct type IV pili in Thermus thermophilus using cryoEM, revealing their structural differences and functional roles in motility and DNA uptake.

Architecture and modular assembly of Sulfolobus S-layers revealed by electron cryo-tomography

This study uses electron cryo-microscopy to reveal the 3D architecture and modular assembly of S-layers in Sulfolobus strains, identifying subunits and proposing an assembly model.

miR-128 inhibits telomerase activity by targeting TERT mRNA

This paper identifies miR-128 as a novel telomerase inhibitor that directly targets TERT mRNA, reducing its expression in cancer cell lines.