Fitness landscape of substrate-adaptive mutations in evolved APC transporters
F. Karapanagioti, U. A. Atlason, D. J. Slotboom, B. Poolman, S. Obermaier
This study shows how mutations in yeast APC transporters expand substrate range while affecting fitness for original substrates, revealing trade-offs in transporter evolution.
bioRxiv · Oct 12, 2023Biochemistry