Author

D. J. Slotboom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. A. Garaeva· 2 shared C. Paulino· 2 shared A. Schlessinger· 1 shared B. Poolman· 1 shared C. A. J. Hutter· 1 shared C. Grewer· 1 shared E. Ndaru· 1 shared F. Karapanagioti· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. A. Garaeva

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Author profile →

4 papers

Recent·Most cited

The S-component fold: A link between bacterial transporters and receptors

M. Partipilo, D. J. Slotboom

The paper identifies a structural link between bacterial transporters and receptors using AI-based structure prediction tools, revealing prokaryotic 'transceptors'.

bioRxiv · Dec 20, 2023Biochemistry

Fitness landscape of substrate-adaptive mutations in evolved APC transporters

F. Karapanagioti, U. A. Atlason, D. J. Slotboom, B. Poolman, S. Obermaier

This study shows how mutations in yeast APC transporters expand substrate range while affecting fitness for original substrates, revealing trade-offs in transporter evolution.

bioRxiv · Oct 12, 2023Biochemistry

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance

J. D. Walter, C. A. J. Hutter, A. A. Garaeva, M. Scherer, I. Zimmermann, M. Wyss, J. Rheinberger, Y. Ruedin, J. C. Earp, P. Egloff, M. Sorgenfrei, L. Hürlimann, I. Gonda, G. Meier, S. Remm, , M. A. Seeger

bioRxiv · Nov 10, 2020Biochemistry

Structural basis for stereospecific inhibition of ASCT2 from rational design

R.-A. A. Garibsingh, E. Ndaru, A. A. Garaeva, M. Bonomi, D. J. Slotboom, C. Paulino, C. Grewer, A. Schlessinger

The paper rationally designs inhibitors for ASCT2 using computational modeling and cryo-EM, showing how stereospecific pockets can be exploited for drug discovery.

bioRxiv · May 29, 2020Biochemistry