Investigating the conformational response of the Sortilin receptor upon binding endogenous peptide- and protein ligands by HDX-MS
E. Trabjerg, N. Abu-Asad, Z. Wan, F. Kartberg, S. Christensen, K. D. Rand
This study uses HDX-MS to analyze how Sortilin's conformation changes upon binding different endogenous ligands, revealing distinct conformational impacts and a potential link between ligand binding and a remote domain.
bioRxiv · Sep 14, 2018Biophysics