S. Christensen

Cross-sector collaboration reduces SARS-CoV-2 risk in deer

The paper models SARS-CoV-2 transmission dynamics in white-tailed deer across sectors and finds that cross-sector collaboration is most effective in reducing risk.

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

DnaK response to expression of protein mutants is dependent on translation rate and stability

The paper investigates how DnaK response to protein mutants depends on translation rate and stability, finding initial response correlates with synthesis rate and later with stability.

A Role for Maternal Factors in Suppressing Cytoplasmic Incompatibility

This study investigates maternal factors in suppressing Cytoplasmic Incompatibility in Drosophila simulans using chemical treatments affecting DNA integrity, cell cycle control, and protein turnover.

Physical constrains and functional plasticity of cellulases: Linear scaling relationships for a heterogeneous enzyme reaction

The paper characterizes 83 cellulases, revealing a linear free energy relationship between substrate binding strength and activation barrier, suggesting physical constraints and evolutionary optimization in interfacial enzyme catalysis.

Ultra-deep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

This study shows that 5-FU treatment causes characteristic T>G mutations in cancer, similar to endogenous mutational signatures, and may increase secondary malignancy risk.

Investigating the conformational response of the Sortilin receptor upon binding endogenous peptide- and protein ligands by HDX-MS

This study uses HDX-MS to analyze how Sortilin's conformation changes upon binding different endogenous ligands, revealing distinct conformational impacts and a potential link between ligand binding and a remote domain.