Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis
A. S. Cloud, M. M. McWilliams, F. Koohestani, S. Ganeshkumar, S. Gunewardena, A. Graham, W. B. Nothnick, V. M. Chennathukuzhi
This study shows that loss of REST in mouse uterus leads to uterine leiomyoma-like gene expression and altered progesterone receptor function, suggesting a mechanism for hormone-related tumor growth.
bioRxiv · Apr 11, 2022Physiology