W. B. Nothnick

Endometrial cyclin A2 deficiency is associated with human female infertility and is recapitulated in a conditional knockout mouse model

This study shows that reduced cyclin A2 expression in endometrial stromal cells is linked to infertility in women and is reproduced in a mouse model with conditional Ccna2 deletion.

Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis

This study shows that loss of REST in mouse uterus leads to uterine leiomyoma-like gene expression and altered progesterone receptor function, suggesting a mechanism for hormone-related tumor growth.