S. Gunewardena

IRAK1 is a critical mediator of low molecular weight hyaluronic acid-induced stemness in high-grade serous ovarian cancer

This study identifies IRAK1 as a key mediator of LMW HA-induced stemness in EOC, showing its role in chemoresistance and demonstrating TCS2210 as a potential inhibitor.

Endometrial cyclin A2 deficiency is associated with human female infertility and is recapitulated in a conditional knockout mouse model

This study shows that reduced cyclin A2 expression in endometrial stromal cells is linked to infertility in women and is reproduced in a mouse model with conditional Ccna2 deletion.

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.

Doublecortin like kinase 1 is a target in squamous cell carcinoma

This study identifies DCLK1 as a critical target in squamous cell carcinoma, showing its role in tumor growth and demonstrating a selective inhibitor, DiFiD, that suppresses cancer progression.

Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis

This study shows that loss of REST in mouse uterus leads to uterine leiomyoma-like gene expression and altered progesterone receptor function, suggesting a mechanism for hormone-related tumor growth.

RNA binding protein RBM3 augments kissing loop formation with lncRNAs to enhance translational control

This study identifies RBM3's role in enhancing translational control via lncRNA kissing loop formation and shows its impact on tumor growth and colitis-associated cancers.

START domain mediates Arabidopsis GLABRA2 transcription factor dimerization and turnover independently of homeodomain DNA binding

This study investigates the role of the START domain in GLABRA2 dimerization and protein turnover, showing it is independent of DNA binding and essential for stability.

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.

Teratogenic Drug Topiramate Upregulates TGFβ1 and SOX9 Expression in Primary Palatal Mesenchyme Cells

This study shows topiramate increases TGFβ1 and SOX9 in palatal mesenchyme cells, potentially causing orofacial clefts through GABA receptor activation.

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Activation is Essential for Termination of Liver Regeneration

This study shows that HNF4α reexpression after liver injury is critical for hepatocytes to exit the cell cycle and resume function during liver regeneration.