Dynamic Disulfide Bond Topologies in von-Willebrand-Factor's C4-Domain Undermine Platelet Binding
F. Kutzki, D. Butera, A. J. Lay, D. M. Maag, J. Chiu, H.-G. Woon, T. Kubar, M. Elstner, C. Aponte-Santamaria, P. Hogg, F. Graeter
This study quantifies disulfide bond topologies in vWF-C4 domain and shows their impact on platelet binding through integrin.
bioRxiv · Aug 20, 2022 · PreprintBiophysics