Author

F. M. Diffin

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Biochemistry· 1

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Approach:experimental assay· 1

Frequent Co-Authors

G. Gasiunas· 1 shared G. Mullally· 1 shared K. van Aelst· 1 shared M. D. Szczelkun· 1 shared M. M. Naqvi· 1 shared T. Karvelis· 1 shared V. Siksnys· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

G. Gasiunas

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1 paper

Recent·Most cited

5' modifications to CRISPR Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

G. Mullally, K. van Aelst, M. M. Naqvi, F. M. Diffin, T. Karvelis, G. Gasiunas, V. Siksnys, M. D. Szczelkun

The paper investigates how 5' modifications to CRISPR gRNA affect R-loop dynamics and DNA cleavage, finding that certain modifications inhibit cleavage while others do not.

bioRxiv · Apr 9, 2020Biochemistry