Author

M. M. Naqvi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Roth· 1 shared E. J. Koers· 1 shared F. M. Diffin· 1 shared G. Gasiunas· 1 shared G. J. Kramer· 1 shared G. Mullally· 1 shared H. S. Rye· 1 shared K. van Aelst· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

A. Roth

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3 papers

Recent·Most cited

A gate and clamp regulate sequential DNA strand cleavage by CRISPR-Cas12a

M. M. Naqvi, L. Lee, O. E. Torres Montaguth, M. Szczelkun

This study investigates how CRISPR-Cas12a cleaves DNA strands sequentially by observing structural changes and using mutagenesis to show the role of a gate and clamp in the process.

bioRxiv · Jun 18, 2021 · PreprintBiochemistry

Polypeptide collapse modulation and folding stimulation by GroEL-ES

M. M. Naqvi, M. J. Avellaneda, A. Roth, E. J. Koers, V. Sunderlikova, G. J. Kramer, H. S. Rye, S. J. Tans

This study shows GroEL-ES enhances polypeptide collapse, directly stimulating folding by pulling chains into its cavity and promoting compaction and folding transitions.

bioRxiv · Jun 17, 2020 · PreprintBiophysics

5' modifications to CRISPR Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

G. Mullally, K. van Aelst, M. M. Naqvi, F. M. Diffin, T. Karvelis, G. Gasiunas, V. Siksnys, M. D. Szczelkun

The paper investigates how 5' modifications to CRISPR gRNA affect R-loop dynamics and DNA cleavage, finding that certain modifications inhibit cleavage while others do not.

bioRxiv · Apr 9, 2020Biochemistry