Decoding the pituitary gonadotrope regulatory architecture governing the preovulatory surge in vivo
Charles Le Ciclé, Ghislaine Garrel, Stéphanie Chauvin, Frank Giton, Olivier Taboureau, F. Miralles, Joëlle Cohen-Tannoudji, David L’Hôte
The paper identifies a biphasic gene regulatory network in rat pituitary gonadotropes that controls the preovulatory hormone surge, showing FSH surge is driven by dynamic Fshb transcription rather than Lhb upregulation.
bioRxiv · Nov 18, 2025 · PreprintPhysiology