Stéphanie Chauvin

The paper identifies a biphasic gene regulatory network in rat pituitary gonadotropes that controls the preovulatory hormone surge, showing FSH surge is driven by dynamic Fshb transcription rather than Lhb upregulation.

This study evaluates SIRT1 inhibition's effect on granulosa cell tumor growth and metastasis using in vitro and in vivo models, finding reduced tumor progression with EX-527 treatment.