Soluble LIGHT (TNFSF14) activates endothelial cells, thereby priming the first vessel-occlusive events in acute sickle cell disease
P. Chadebech, K.-A. Nguyen-Peyre, G. Di Liberto, G. Bodivit, F. Pirenne, P. Bartolucci
This study shows that soluble LIGHT levels are elevated in SCD patients during acute crises and promote endothelial activation, leading to platelet and RBC adhesion, which may initiate vaso-occlusion.
bioRxiv · Jun 8, 2023 · PreprintCell Biology