Contribution of amino acids in the Active site of Dipeptidyl Peptidase 4 to the catalytic action of the enzyme
K. Gnoth, J. W. Bär, F. Rosche, J. U. Rahfeld, H.-U. Demuth
The paper investigates the role of specific amino acids in the active site of Dipeptidyl Peptidase 4 (DP4) in inhibitor binding and substrate catalysis, identifying key residues involved in substrate discrimination and catalytic activity.
bioRxiv · Jul 14, 2023Biochemistry