Author

F. Ruchti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. LeibundGut-Landmann· 4 shared G. Ianiri· 2 shared J. Heitman· 2 shared B. Becher· 1 shared C. Fu· 1 shared D. Fox· 1 shared F. Dietrich· 1 shared F. Sparber· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

S. LeibundGut-Landmann

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4 papers

Recent·Most cited

Epidermal barrier dysregulation in atopic skin predisposes for excessive growth of the allergy-associated yeast Malassezia

F. Ruchti, P. Zwicky, B. Becher, S. Dubrac, S. LeibundGut-Landmann

This study shows that impaired skin barriers in atopic dermatitis allow Malassezia yeast to grow more efficiently due to changes in the skin's lipid environment.

bioRxiv · Sep 11, 2023 · PreprintMicrobiology

γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.

F. Ruchti, M. Tuor, L. Mathew, N. McCarthy, S. LeibundGut-Landmann

This study identifies Vγ4+ γδ T cells as key mediators of IL-17-dependent fungal control against Malassezia in skin, showing memory-like responses and direct recognition of fungal ligands.

bioRxiv · Sep 8, 2023 · PreprintImmunology

Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction

G. Ianiri, M. A. Coelho, F. Ruchti, F. Sparber, T. J. McMahon, C. Fu, M. Bolejack, O. Donovan, H. Smutney, P. Myler, F. Dietrich, D. Fox, S. LeibundGut-Landmann, J. Heitman

This study identifies bacterially-derived flavohemoglobin in Malassezia, acquired via horizontal gene transfer, as essential for nitric oxide resistance and host interaction.

Proceedings of the National Academy of Sciences · Jun 23, 2020Peer-reviewedMicrobiology

A novel mycovirus evokes transcriptional rewiring in the fungus Malassezia and stimulates interferon-β production in macrophages

S. A. Clancey, F. Ruchti, S. LeibundGut-Landmann, J. Heitman, G. Ianiri

This study identifies a novel mycovirus in Malassezia that alters transcriptional profiles and induces interferon-β in macrophages, suggesting potential implications for fungal pathogenicity.

bioRxiv · Dec 18, 2019Microbiology