Author

M. A. Coelho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Evolutionary Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Assay:DNA methylation· 4 Organism:fungi (other)· 4 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3

Frequent Co-Authors

J. Heitman· 8 shared M. Nowrousian· 4 shared S. Sun· 4 shared A. F. Averette· 2 shared A. R. Passer· 2 shared C. A. Cuomo· 2 shared C. Fu· 2 shared M. David-Palma· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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8 shared papersMicrobiology

J. Heitman

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex

A. R. Passer, S. A. Clancey, T. Shea, M. David-Palma, A. F. Averette, T. Boekhout, B. M. Porcel, M. Nowrousian, C. A. Cuomo, S. Sun, J. Heitman, M. A. Coelho

This study identifies the genetic mechanism enabling self-compatible sexual reproduction in Cryptococcus depauperatus, a fungus closely related to human pathogens.

bioRxiv · Mar 30, 2022Microbiology

Base editing screens map mutations affecting IFNγ signalling in cancer

M. A. Coelho, E. Karakoc, S. G. Bhosle, E. Goncalves, T. Burgold, S. Cooper, C. M. Cattaneo, V. Veninga, S. Consonni, C. Dincer, S. F. Vieira, F. Gibson, S. Barthorpe, C. Hardy, J. Rein, , M. J. Garnett

This study uses base editing to identify mutations affecting IFNγ signalling in cancer, revealing loss- and gain-of-function variants with clinical relevance.

bioRxiv · Mar 29, 2022 · PreprintCancer Biology

Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans

C. Fu, A. Davy, S. Holmes, S. Sun, V. Yadav, A. A. Gusa, M. A. Coelho, J. Heitman

This study identifies cell cycle regulators involved in ploidy transitions during unisexual reproduction in C. deneoformans and reveals segmental aneuploidy associated with azole resistance.

bioRxiv · Jun 1, 2021Microbiology

Multiple pathways to homothallism in closely related yeast lineages in the Basidiomycota

A. Cabrita, M. David-Palma, P. H. Brito, J. Heitman, M. A. Coelho, P. Goncalves

This study identifies distinct molecular mechanisms of homothallism in two closely related yeast species, suggesting independent evolution of this trait within the Cystofilobasidiales lineage.

bioRxiv · Sep 30, 2020Microbiology

Horizontal gene transfer in the human and skin commensal Malassezia: a bacterially-derived flavohemoglobin is required for NO resistance and host interaction

G. Ianiri, M. A. Coelho, F. Ruchti, F. Sparber, T. J. McMahon, C. Fu, M. Bolejack, O. Donovan, H. Smutney, P. Myler, F. Dietrich, D. Fox, S. LeibundGut-Landmann, J. Heitman

This study identifies bacterially-derived flavohemoglobin in Malassezia, acquired via horizontal gene transfer, as essential for nitric oxide resistance and host interaction.

Proceedings of the National Academy of Sciences · Jun 23, 2020Peer-reviewedMicrobiology

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

Y. Fang, M. A. Coelho, H. Shu, K. Schotanus, B. C. Thimmappa, V. Yadav, H. Chen, E. P. Malc, J. Wang, P. Mieczkowski, B. Kronmiller, B. M. Tyler, K. Sanyal, S. Dong, M. Nowrousian, J. Heitman

This paper identifies centromeres in Phytophthora sojae using long-read sequencing and ChIP-seq, revealing transposon-rich, heterochromatic regions distinct from other SAR supergroup organisms.

bioRxiv · Jan 30, 2020Microbiology

Convergent evolution of linked mating-type loci in basidiomycete fungi

S. Sun, M. A. Coelho, J. Heitman, M. Nowrousian

The paper analyzes mating-type loci in Trichosporonales fungi, showing fused MAT loci with conserved gene order, supporting convergent evolution of linked mating-type regions.

bioRxiv · Aug 6, 2019Evolutionary Biology

Genetic and genomic analyses reveal boundaries between species closely related to Cryptococcus pathogens

A. R. Passer, M. A. Coelho, R. B. Billmyre, M. Nowrousian, M. Mittelbach, A. M. Yurkov, A. F. Averette, C. A. Cuomo, S. Sun, J. Heitman

This study uses genomic analysis to identify three genetically distinct species within the Cryptococcus amylolentus complex, revealing chromosomal rearrangements and reproductive barriers.

bioRxiv · Feb 22, 2019Evolutionary Biology

Cryptococcus deuterogattii VGIIa infection associated with travel to the Pacific Northwest outbreak region in an anti-GM-CSF autoantibody positive patient in the United States

S. A. Clancey, E. J. Ciccone, M. A. Coelho, J. Davis, L. Ding, R. Betancourt, S. Glaubiger, Y. Lee, S. M. Holland, P. Gilligan, J. Sung, J. Heitman

This paper reports a case of C. deuterogattii VGIIa infection in a U.S. patient linked to travel to the PNW outbreak region and associated with anti-GM-CSF autoantibodies.

bioRxiv · Jan 8, 2019Microbiology