Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures
Y. Hiruma, A. Koch, N. Hazraty, F. Tsakou, R. H. Medema, R. P. Joosten, A. Perrakis
The paper characterizes inhibitor resistance in Mps1 mutants using biophysical assays and crystal structures, showing that Cpd-5 is better tolerated than NMS-P715 in resistant mutants.
bioRxiv · Jul 18, 2017Biochemistry