Author

R. P. Joosten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Perrakis· 4 shared A. Koch· 1 shared A. Sonnenberg· 1 shared B. van Beusekom· 1 shared F. Tsakou· 1 shared G. L. Gilliland· 1 shared G. Rajagopal· 1 shared J. Luo· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

A. Perrakis

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Author profile →

4 papers

Recent·Most cited

Caskin2 is a novel talin and Abi1-binding protein that promotes cell motility

W. Wang, P. Atherton, M. Kreft, L. te Molder, S. van der Poel, L. Hoekman, P. Celie, R. P. Joosten, R. Faessler, A. Perrakis, A. Sonnenberg

This study identifies Caskin2 as a novel talin-binding protein that enhances cell motility through interactions with Abi1 and the WAVE Regulatory Complex.

bioRxiv · Mar 15, 2024Cell Biology

A global Ramachandran score identifies protein structures with unlikely stereochemistry

O. V. Sobolev, P. V. Afonine, N. W. Moriarty, M. L. Hekkelman, R. P. Joosten, A. Perrakis, P. D. Adams

The paper introduces a re-implemented Ramachandran Z-score and its uncertainty estimation for protein structure validation, advocating its inclusion in structural publications and validation reports.

bioRxiv · Mar 26, 2020Biophysics

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

Y. Hiruma, A. Koch, N. Hazraty, F. Tsakou, R. H. Medema, R. P. Joosten, A. Perrakis

The paper characterizes inhibitor resistance in Mps1 mutants using biophysical assays and crystal structures, showing that Cpd-5 is better tolerated than NMS-P715 in resistant mutants.

bioRxiv · Jul 18, 2017Biochemistry

Homology-based hydrogen bond information improves crystallographic structures in the PDB

B. van Beusekom, W. G. Touw, M. Tatineni, S. Somani, G. Rajagopal, J. Luo, G. L. Gilliland, A. Perrakis, R. P. Joosten

The paper improves low-resolution crystallographic structures by incorporating homology-derived hydrogen bond restraints.

bioRxiv · Jun 21, 2017Biochemistry