Author

Y. Hiruma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Perrakis· 3 shared A. Koch· 1 shared F. Tsakou· 1 shared G. J. Kops· 1 shared G. Kops· 1 shared G. Spyroulias· 1 shared M. Ubbink· 1 shared M.-T. Matsoukas· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

A. Perrakis

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3 papers

Recent·Most cited

The MPS1 kinase NTE region has helical propensity and preferred conformations towards the TPR domain

Y. Hiruma, M.-T. Matsoukas, W. Touw, G. Spyroulias, G. Kops, M. Ubbink, A. Perrakis

This study investigates the conformational dynamics of the MPS1 kinase NTE region relative to the TPR domain using paramagnetic NMR and Rosetta, revealing helical propensity and convex surface interactions.

bioRxiv · Mar 31, 2020 · PreprintBiochemistry

Interactions between N-terminal modules in MPS1 enable spindle checkpoint silencing

S. T. Pachis, Y. Hiruma, A. Perrakis, G. J. Kops

This study identifies an NTE-TPR interaction in MPS1 essential for SAC silencing by regulating MPS1 localization and delocalization from kinetochores.

bioRxiv · Oct 10, 2018Cell Biology

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

Y. Hiruma, A. Koch, N. Hazraty, F. Tsakou, R. H. Medema, R. P. Joosten, A. Perrakis

The paper characterizes inhibitor resistance in Mps1 mutants using biophysical assays and crystal structures, showing that Cpd-5 is better tolerated than NMS-P715 in resistant mutants.

bioRxiv · Jul 18, 2017Biochemistry