Author

F.-L. Hsieh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

T.-H. Chang· 3 shared E. Y. Jones· 2 shared K. Harlos· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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3 shared papersBiochemistry

T.-H. Chang

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3 papers

Recent·Most cited

Structural basis of Norrin recognition by Lgr4/5/6

T.-H. Chang, K. Harlos, F.-L. Hsieh, E. Y. Jones

The paper determines the structure of Norrin bound to Lgr4ECD, showing conserved binding residues and overlapping binding sites with Rspo1 and Fz4CRD.

bioRxiv · Sep 29, 2022 · PreprintBiochemistry

Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain

T.-H. Chang, F.-L. Hsieh, K. Harlos, E. Y. Jones

The paper reports structures of Frizzled domains complexed with acylated Wnt peptide, revealing different dimer conformations and interactions that inform Fz function modulation.

bioRxiv · Sep 29, 2022 · PreprintBiochemistry

Antibody Display of cell surface receptor Tetraspanin12 and SARS-CoV-2 spike protein

F.-L. Hsieh, T.-H. Chang

The paper develops an Antibody Display technology to graft proteins onto antibody CDR3 regions, demonstrating binding of Tspan12EC2 to Norrin and SARS-CoV-2 RBD to ACE2.

bioRxiv · May 29, 2021 · PreprintBioengineering