Author

K. Harlos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Y. Jones· 3 shared B. Lee· 2 shared F.-L. Hsieh· 2 shared I. Rissanen· 2 shared T. A. Bowden· 2 shared T.-H. Chang· 2 shared A. J. McMichael· 1 shared A. J. Stelfox· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

E. Y. Jones

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Author profile →

5 papers

Recent·Most cited

Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein

A. J. Stelfox, K. Y. Oguntuyo, I. Rissanen, K. Harlos, R. Rambo, B. Lee, T. A. Bowden

This paper determines the crystal structure and solution state of the C-terminal head region of the receptor-binding proteins from Mossman and Nariva viruses, revealing structural differences from other paramyxoviruses.

mBio · Oct 31, 2023Peer-reviewedBiochemistry

Structural basis of Norrin recognition by Lgr4/5/6

T.-H. Chang, K. Harlos, F.-L. Hsieh, E. Y. Jones

The paper determines the structure of Norrin bound to Lgr4ECD, showing conserved binding residues and overlapping binding sites with Rspo1 and Fz4CRD.

bioRxiv · Sep 29, 2022 · PreprintBiochemistry

Structural insights into Frizzled assembly by acylated Wnt and Frizzled Connector domain

T.-H. Chang, F.-L. Hsieh, K. Harlos, E. Y. Jones

The paper reports structures of Frizzled domains complexed with acylated Wnt peptide, revealing different dimer conformations and interactions that inform Fz function modulation.

bioRxiv · Sep 29, 2022 · PreprintBiochemistry

Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity

D. Li, S. Brackenridge, L. C. Walters, O. Swanson, K. Harlos, D. Rozbesky, D. W. Cain, K. Wiehe, R. M. Scearce, M. Barr, Z. Mu, R. Parks, M. Quastel, R. J. Edwards, Y. Wang, , B. F. Haynes

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

bioRxiv · Dec 3, 2020Immunology

A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

R. Pryce, K. Azarm, I. Rissanen, K. Harlos, T. A. Bowden, B. Lee

This study identifies a key molecular region in Cedar virus glycoprotein that determines its unique utilization of ephrin-B1 as an entry receptor, distinct from other HNVs.

bioRxiv · Aug 5, 2019Microbiology