Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants
F. Fan, X. Zhang, Z. Zhang, Y. Ding, L. Wang, X. Xu, Y. Pan, F.-Y. Gong, L. Jiang, L. Kang, Z. Kou, G. Zhao, B. Wang, X.-M. Gao
This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.
bioRxiv · Dec 1, 2022Immunology