A new mechanism of regulation of LIM kinases, LIMK1 and LIMK2, modulates their activity on cofilin and actin filament remodelling
Elodie Villalonga-Rosso, Amandine Serrano, Cristine Gonçalves, Samia Aci‐Sèche, Déborah Cassas, Célina Chalal, Bojan Žunar, Michel Doudeau, Christine Mosrin-Huaman, Fabienne Godin, Pascal Bonnet, Hélène Bénédetti, Béatrice Vallée
The paper identifies a critical amino acid residue that mediates LIMK dimerization and transphosphorylation, essential for their activity on cofilin and actin filament remodeling.
bioRxiv · Jun 23, 2026 · PreprintMolecular Biology