Marcin J. Suskiewicz

A new class of inherently efficient SUMOylation substrates

This paper identifies a new class of inherently efficient SUMOylation substrates by showing that ZBTB38BTB and related BTB domains can be SUMOylated efficiently without E3 ligase involvement.

Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L

This study shows that nucleic acids can be ubiquitylated by DTX3L, an E3 ligase, and this modification is reversible by DUBs like USP2 and SARS-CoV-2 PLpro.

Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants

The paper identifies a noncanonical SUMOylation motif in Nf1's SecPH domain that correlates with pathogenic mutants' folding defects.

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

This study elucidates how McsB, a bacterial kinase, regulates protein degradation by switching between open and closed oligomer forms in response to stress.