Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants
Mohammed Bergoug, Christine Mosrin-Huaman, Fabienne Godin, Michel Doudeau, Iva Sosic, Marcin J. Suskiewicz, Béatrice Vallée, Hélène Bénédetti
The paper identifies a noncanonical SUMOylation motif in Nf1's SecPH domain that correlates with pathogenic mutants' folding defects.
bioRxiv · Dec 9, 2021 · PreprintMolecular Biology