Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo
Joshua James Shrouder, Gian Marco Calandra, Severin Filser, Dániel Péter Varga, Simon Besson‐Girard, Uta Mamrak, Maximilian Dorok, Buket Bulut-Impraim, Fatma Burcu Şeker, Benno G. Gesierich, Fabio Laredo, Antonia Clarissa Wehn, Igor Khalin, Patrick J. Bayer, Arthur Liesz, , Nikolaus Plesnila
The paper shows pericytes constrict during ischemia, remain constricted post-reperfusion, and contribute to no-reflow, with some surviving and upregulating transcripts, suggesting they are therapeutic targets.
Brain · Nov 29, 2023Peer-reviewedNeuroscience