Cell Painting and chemical structure read-across can complement each other for rat acute oral toxicity prediction in chemical early de-risking
Fabrice Camilleri, Joanna M. Wenda, Claire Pecoraro-Mercier, Jean‐Paul Comet, David Rouquié
The paper evaluates read-across methods for predicting rat acute oral toxicity using chemical structure and Cell Painting data, finding chemical structure is more predictive for similar compounds while morphology is better for dissimilar ones.
Chemical Research in Toxicology · Nov 8, 2024Peer-reviewedPharmacology & Toxicology