Joanna M. Wenda

Large-scale experimental validation of phenotype-guided generative AI for de novo drug discovery

The paper validates a generative AI model using experimental assays to design small molecule drugs targeting specific cancer-related phenotypes, showing 88% morphological impact and 37% transcriptomic pathway effects.

Transgenerational maintenance of H3K27me3 heterochromatin is balanced by chromodomain proteins in Caenorhabditis elegans

The paper shows that altered H3K27me3 landscapes can be inherited across generations in C. elegans, regulated by chromodomain proteins with opposing roles.

Cell Painting and chemical structure read-across can complement each other for rat acute oral toxicity prediction in chemical early de-risking

The paper evaluates read-across methods for predicting rat acute oral toxicity using chemical structure and Cell Painting data, finding chemical structure is more predictive for similar compounds while morphology is better for dissimilar ones.

Trans-generational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line

The paper shows that the N-terminal tail of CENP-A is required for de novo centromere establishment in C. elegans germ line but not for maintenance during embryogenesis.

Loss of histone H3.3 results in DNA replication defects and altered origin dynamics in C. elegans

This study shows that loss of histone H3.3 in C. elegans embryos causes replication defects, altered origin dynamics, and increased lethality under stress.

Local inhibition of PRC2 activity by H3.3K27M drives DNA replication defects through misregulation of the JNK pathway

This study shows that H3.3K27M mutation causes DNA replication defects via JNK pathway misregulation in C. elegans, with implications for human tumor treatment.