High glucose levels impair the body's renal protective function during water deprivation by blunting the FXR-TonEBP axis
Tuo Wei, Jiebo Huang, Yan Li, Liru Yin, Fang Tian, Qiong Wang, Enchao Zhou
The paper shows high glucose levels reduce kidney protection during dehydration by inhibiting the FXR-TonEBP axis in diabetic patients and mice.
bioRxiv · Jul 11, 2025 · PreprintPhysiology