Single-cell transcriptome lineage tracing of human pancreatic development identifies distinct developmental trajectories of alpha and beta cells
Li Lin, Yufeng Zhang, Weizhou Qian, Yao Liu, Yingkun Zhang, Fanghe Lin, Cenxi Liu, Guangxing Lu, Yanling Song, Jia Tao Song, Chaoyong James Yang, Jin Li
This study uses single-cell RNA-seq and mitochondrial variants to trace lineage differences between alpha and beta cells in human pancreatic development, revealing distinct developmental trajectories not seen in mice.
bioRxiv · Jan 14, 2021 · PreprintDevelopmental Biology