Jin Li

The paper determines the crystal structure of Egalitarian bound to an mRNA localization signal, revealing structural features essential for RNA recognition and function.

scBiopsy-seq enables temporal single-cell RNA-seq analysis with high detection diversity and reliability, revealing key roles of fatty acid beta oxidation in transcriptional suppression.

This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.

This study shows that excessive fructose worsens heart failure in obese mice by impairing fatty acid oxidation and the AMPK-ACC pathway.

The paper creates a comprehensive human retina cell atlas using single-cell multi-omics data, revealing over 110 cell types and their gene regulatory networks, and enables fine-mapping of GWAS and eQTL variants.

mitoSplitter uses mitochondrial RNA variants to demultiplex pooled single-cell RNA-seq data, enabling efficient analysis of multiple samples without batch effects.

The paper performs spatial transcriptomic profiling of the mouse retina to uncover its laminar organization and generates a comprehensive spatial single cell reference atlas.

The paper models scRNA-seq data from developmental processes using SDEs to identify transition cells that explain heterogeneity and predict cell fate in early tumorigenesis.

This study shows that mesothelial cells are not a source of visceral adipocytes in mice, challenging a recent paradigm based on Wt1 lineage tracing.

This study uses single-cell RNA-seq and mitochondrial variants to trace lineage differences between alpha and beta cells in human pancreatic development, revealing distinct developmental trajectories not seen in mice.

The paper shows that Rho-kinase membrane residence time is regulated by phospho-modulation at tissue boundaries, affecting planar polarization during morphogenesis.