Yufeng Zhang

TrajAtlas explores multi-scale heterogeneity in osteogenesis by analyzing cell, gene, and gene module differentiation across age and injury conditions.

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

This study uses single-cell RNA-seq and mitochondrial variants to trace lineage differences between alpha and beta cells in human pancreatic development, revealing distinct developmental trajectories not seen in mice.