Yingkun Zhang

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

mitoSplitter uses mitochondrial RNA variants to demultiplex pooled single-cell RNA-seq data, enabling efficient analysis of multiple samples without batch effects.

This study uses single-cell RNA-seq and mitochondrial variants to trace lineage differences between alpha and beta cells in human pancreatic development, revealing distinct developmental trajectories not seen in mice.