Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
Gaël Barthet, Tomás Jordá-Siquier, Julie Rumi, Fanny Bernadou, Ulrike C. Müller, Christophe Mulle
This study shows that presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity, linking APP processing to synaptic function in Alzheimer's disease.
Nature Communications · Nov 8, 2018Peer-reviewedNeuroscience