Tomás Jordá-Siquier

This paper introduces mCleLight, a method for clearing, labeling, and imaging whole human tissues, enabling multiscale analysis of organ architecture.

CleLight improves transparency and reduces autofluorescence in human brain tissue, enabling detailed imaging of pathological features in archival samples.

The paper introduces pAPRica, a framework for efficient analysis of large-scale histopathology images, achieving significant speedup and data reduction.

This study identifies reduced presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease, suggesting presynaptic failure in this region.

This study shows that presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity, linking APP processing to synaptic function in Alzheimer's disease.