OVEREXPRESSION OF TUMORPROTECTIVE CLUSTERIN PREVENTS EXHAUSTION OF TRANSGENIC T CELLS
Constantin Segner, Yue Z. Huang, Elena Sotillo, Busheng Xue, Yidan Wang, Mansour Poorebrahim, Julia Hoebart, Michael Lizardo, Julia Mergner, Fares Burwag, Miriam Schulz, Andrew Ivor Minchinton, Christian Brueckner, Alissia Fernandes Madeira, Alisa Kolesnikova, , Stefan E.G. Burdach
This study shows that overexpressing clusterin (CLU) in T cells reduces exhaustion markers and improves their function against Ewing sarcoma.
bioRxiv · Dec 18, 2025 · PreprintImmunology