Evidence that Dmrta2 acts as a transcriptional repressor of Pax6 in murine cortical progenitors and identification of a mutation crucial for DNA recognition associated with microcephaly in human
Xueyi Shen, Jithu Anirudhan, Ambrin Fatima, Tünde Szemes, Marc Keruzoré, Estelle Plant, Alba Sabaté San José, Sadia Kricha, Louis Delhaye, Bilal Ahmad Mian, Lubaba Bintee Khalid, Farhan Ali, Hijab Zahra, Asmat Ali, Mathias Toft, , Eric Bellefroid
This study shows Dmrta2 represses Pax6 in cortical progenitors and identifies a DNA-binding mutation linked to microcephaly in humans.
bioRxiv · Sep 20, 2024 · PreprintNeuroscience