AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in mice
Maya Dannawi, Luke A. Pattison, Alexander Cloake, Eric Bellefroid, Ewan St. John Smith
This study shows that overexpressing Prdm12 in knee-innervating neurons reduces inflammatory joint pain and neuronal hyperexcitability in mice.
bioRxiv · Oct 14, 2025 · PreprintNeuroscience