A nuclease-driven mechanism of post-replicative ssDNA gap suppression.
Laura G. Bennett, Vithursha Thanendran, Daniel Harrison, Caryl M Jones, Fay Antonopoulou, J Rajan, Ellen G Vernon, Amelia Gamble, Rolf Kraehenbuehl, Edgar Hartsuiker, Christopher J. Staples
This paper identifies a nuclease-driven mechanism for suppressing post-replicative ssDNA gaps, showing that MRNIP loss leads to MRE11-dependent gap filling via template switching.
bioRxiv · Oct 22, 2025 · PreprintCancer Biology