Ellen G Vernon

This paper shows that IFI16 detects stalled replication forks and triggers an innate immune response, while also protecting nascent DNA from degradation and aiding in fork protection in BRCA-deficient cells.

This paper identifies a nuclease-driven mechanism for suppressing post-replicative ssDNA gaps, showing that MRNIP loss leads to MRE11-dependent gap filling via template switching.

This study identifies ISG15 as a key host defense mechanism against Salmonella typhoid toxin, showing it promotes cell survival and reduces bacterial burden through a STING-dependent pathway.