IFI16 senses and protects stalled replication forks
Amelia Gamble, Thomas A. Ward, Otto P.G. Wheeler, Jessica P. Morris, Caryl M Jones, Laura G. Bennett, Ellen G Vernon, Vithursha Thanendran, Ilaria Ceppi, Swagata Halder, Damiano Borrello, Thomas D. J. Walker, Jahnavi Rajan, Hadil Suleiman, Daniel Harrison, , Christopher J. Staples
This paper shows that IFI16 detects stalled replication forks and triggers an innate immune response, while also protecting nascent DNA from degradation and aiding in fork protection in BRCA-deficient cells.
Molecular Cell · Jan 1, 2026Peer-reviewedCancer Biology