Somatic mutant selection is altered by prior NOTCH1 mutation in aging esophageal epithelium
Charlotte King, Joanna C. Fowler, Emilie Abby, Kasumi Murai, Roshan K. Sood, Irina Abnizova, Salomé Brunon, Swee Hoe Ong, Faye Lynch Williams, Michael W.J. Hall, Benjamin A. Hall, Philip H. Jones
The paper shows that prior NOTCH1 mutation in aging esophageal epithelium alters the selection of subsequent somatic mutations, increasing NOTCH2 mutants and decreasing TP53 mutants.
bioRxiv · Sep 26, 2024 · PreprintGenomics