Michael Hall

The paper shows that prior NOTCH1 mutation in aging esophageal epithelium alters the selection of subsequent somatic mutations, increasing NOTCH2 mutants and decreasing TP53 mutants.

The paper shows that p53 and DN_Maml1 mutations have different clonal fitness responses to cell crowding in epithelial tissues, consistent with mutation distributions in human datasets.

The paper compares methods for analysing lineage tracing datasets and recommends an approximate Bayesian computation approach for parameter estimation.