Philip H. Jones

The paper reports mutation rates and mutational signatures across 53 normal human cell types, revealing variation in mutation accumulation and identifying known and unknown mutational processes.

The paper identifies an estrogen receptor/E2F1/CDKN3 axis that protects female mice and humans from UV-induced skin cancers by modulating cell proliferation and differentiation.

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

The paper shows that prior NOTCH1 mutation in aging esophageal epithelium alters the selection of subsequent somatic mutations, increasing NOTCH2 mutants and decreasing TP53 mutants.

The paper shows that p53 and DN_Maml1 mutations have different clonal fitness responses to cell crowding in epithelial tissues, consistent with mutation distributions in human datasets.

The paper compares methods for analysing lineage tracing datasets and recommends an approximate Bayesian computation approach for parameter estimation.