Cancer BiologybioRxivPreprint
Overcoming ibrutinib resistance by targeting phosphatidylinositol-3-kinase signaling in diffuse large B-cell lymphoma
Neeraj Jain, Ondrej Havranek, Ram Kumar Singh…·Felipe Samaniego
This study identifies phosphatidylinositol-3-kinase-beta upregulation as a mechanism of ibrutinib resistance in diffuse large B-cell lymphoma and shows that targeting this pathway with KA2237 can overcome resistance.
DOI 10.1101/523761