Lalit Sehgal

The paper designs and evaluates amino-acid-derived PP2A activators, identifies XML-3D as a lead compound with improved cytotoxicity compared to FTY-720 and OSU-2S.

This study identifies BRG1-driven ferroptosis resistance as a mechanism of BTKi resistance in MCL and shows that BRG1 inhibition restores ferroptotic sensitivity and synergizes with BTKi.

This study identifies phosphatidylinositol-3-kinase-beta upregulation as a mechanism of ibrutinib resistance in diffuse large B-cell lymphoma and shows that targeting this pathway with KA2237 can overcome resistance.