Human- and Rodent-derived Extracellular Vesicles Mediate the Spread of Pathology in MSA-like Models
Maria Vetsi, Dimitra Dionysopoulou, Panagiota Mavroeidi, Fedra Arvanitaki, Grigoria Tsaka, Hele Matinopoulos Lopez, M. Giannopoulou, Sotirios P. Fortis, Anastasios G. Kriebardis, Stefan Becker, Milan Zachrdla, Maria-Sol Cima Omori, Ismini Kloukina, Ioanna Tremi, Sofia Havaki, , Maria Xilouri
The paper investigates the role of oligodendroglial-derived extracellular vesicles in spreading pathology in MSA-like models, showing they carry pathological Synuclein and TPPP/p25 and induce disease in animal models.
bioRxiv · May 12, 2025 · PreprintNeuroscience