Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency
Katerina Konstantoulea, Meine Ramakers, Sarah Catherine Borrie, Dries T’Syen, Daan Moechars, Małgorzata Alicja Śliwińska, Brajabandhu Pradhan, Giulia Albertini, Grigoria Tsaka, Bert Houben, Mark W. E. J. Fiers, Maarten Dewilde, Dietmar Rudolf Thal, Willem Michael, Jonas J. Neher, , Joost W. H. Schymkowitz
This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.
bioRxiv · Oct 11, 2025 · PreprintBiochemistry